抗惊厥药物对雄性大鼠发育及其生育能力的影响。
The effect of anticonvulsant drugs on the development of male rats and their fertility.
作者信息
Cohn D F, Homonnai Z T, Paz G F
出版信息
J Neurol Neurosurg Psychiatry. 1982 Sep;45(9):844-6. doi: 10.1136/jnnp.45.9.844.
Albino male rats were injected with diphenylhydantoin, carbamazepine, valproic acid or clonazepam for three months immediately after weaning. Following the treatment the fertility of the rats was tested by caging them with proestrus females and recording impregnations. The males were decapitated and their sex organs weighed. Epididymal sperm content and motility rate were recorded. A decrease in the prostate weight was found in the valproic acid and the carbamazepine treated rats. Epididymal weights were found decreased only in the valproic acid treated rats. These rats had diminished sperm content and sperm motility and their fertility was decreased. Carbamazepine treated rats had a lowered epididymal sperm content which did not affect their fertility.
白化雄性大鼠在断奶后立即注射苯妥英、卡马西平、丙戊酸或氯硝西泮，持续三个月。治疗后，将这些大鼠与处于发情前期的雌性大鼠关在一起并记录受孕情况，以此来测试大鼠的生育能力。然后将雄性大鼠断头并称量其性器官重量。记录附睾精子含量和活力率。发现丙戊酸和卡马西平治疗的大鼠前列腺重量减轻。仅在丙戊酸治疗的大鼠中发现附睾重量减轻。这些大鼠的精子含量和精子活力降低，生育能力也下降。卡马西平治疗的大鼠附睾精子含量降低，但这并未影响其生育能力。
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