Szende B, Lapis K, Simon K
Neoplasma. 1982;29(4):427-39.
E-N-L-trimethyl lysine (TML) decreases the toxicity of Vincristin, Cyclophosphamide and Doxorubicin (Adriamycin) when administered simultaneously to healthy mice. Simultaneous treatment of L1210 ascites leukemia bearing mice with 100 mg/kg TML and 2, 2.5, 3.2, 3.5, 4 mg/kg Vincristin or 10-15; 20 mg/kg Doxorubicin increases significantly the survival of the animals when compared with untreated and Vincristin or Doxorubicin treated mice. Repeated impulse treatment of S-180 subcutaneous sarcoma with 100 mg/kg TML and 50-100 mg/kg Cyclophosphamide results in a significantly higher surviving time and surviving rate than Cyclophosphamide treatment alone.
E-N-L-三甲基赖氨酸（TML）在与健康小鼠同时给药时，可降低长春新碱、环磷酰胺和阿霉素（阿霉素）的毒性。用100mg/kg TML和2、2.5、3.2、3.5、4mg/kg长春新碱或10-15、20mg/kg阿霉素同时治疗携带L1210腹水白血病的小鼠，与未治疗及长春新碱或阿霉素治疗的小鼠相比，可显著提高动物的存活率。用100mg/kg TML和50-100mg/kg环磷酰胺对S-180皮下肉瘤进行重复脉冲治疗，其存活时间和存活率显著高于单独使用环磷酰胺治疗。
