Messing R B, Rigter H, Nickolson V J
Neurobiol Aging. 1982 Summer;3(2):133-9. doi: 10.1016/0197-4580(82)90009-4.
Alterations in memory storage processes that occur in senescence were investigated by challenging young and old female "small Wistar" rats with posttraining administration of CO2, amphetamine or morphine, and measuring retention performance. Neither duration of CO2 immersion, nor the time of CO2 immersion after training had a differential amnestic effect with age on retention of a one-trial, shock-motivated inhibitory avoidance task. These results indicate that the times during which memory is susceptible to disruption for old and young rats are similar. Challenge with drugs, however, did reveal age-related alterations in memory storage processes. Amphetamine attenuated CO2-induced amnesia in young rats, but had no effect in old rats. This could not be attributed to a general decline in response to amphetamine in old rats because amphetamine increased open field activity of both young and old animals. Morphine also had a differential effect on memory with age: it caused amnesia in old rats trained in a one-trial hot plate escape task, while having no effect on retention performance of young rats. Thus, the modulatory influence of catecholamine and opioid systems on memory processes is probably altered in senescence.
通过在训练后给年轻和老年雌性“小Wistar”大鼠注射二氧化碳、苯丙胺或吗啡，并测量记忆保持表现，来研究衰老过程中发生的记忆存储过程的变化。二氧化碳浸泡的持续时间以及训练后二氧化碳浸泡的时间，对单次试验、电击驱动的抑制性回避任务的记忆保持，均未产生与年龄相关的差异性遗忘效应。这些结果表明，年轻和老年大鼠记忆易受干扰的时间相似。然而，药物激发确实揭示了记忆存储过程中与年龄相关的变化。苯丙胺减轻了年轻大鼠中二氧化碳诱导的遗忘，但对老年大鼠没有影响。这不能归因于老年大鼠对苯丙胺反应的普遍下降，因为苯丙胺增加了年轻和老年动物的旷场活动。吗啡对记忆也有与年龄相关的差异性影响：它在单次试验热板逃避任务中训练的老年大鼠中引起遗忘，而对年轻大鼠的记忆保持表现没有影响。因此，儿茶酚胺和阿片系统对记忆过程的调节影响在衰老过程中可能发生了改变。
