Cohen M
Nouv Presse Med. 1982 Aug 28;11(33):2475-80.
Pirprofen is a new non-steroidal anti-inflammatory drug. Its formula is 2 - (3 - chloro - 4 (3 - pyrrolin - 1 - yl)-phenyl) propionic acid. As demonstrated by the nitrogen nucleus and the the 2 pKA values, the molecule is similar to that of an amino acid. The classical pharmacological studies have proven its powerful anti-inflammatory action. Certain new techniques have enabled the identification of the mechanism of action of pirprofen in the inflammatory process. In addition, pirprofen seems able to slow down the evolution of certain experimental models of osteoarthritis. The mechanism of this effect is unknown.
吡洛芬是一种新型非甾体抗炎药。其分子式为2 - (3 - 氯 - 4 (3 - 吡咯啉 - 1 - 基)-苯基)丙酸。从氮核和两个pKa值可以看出，该分子与氨基酸分子相似。经典药理学研究已证实其具有强大的抗炎作用。某些新技术已能够确定吡洛芬在炎症过程中的作用机制。此外，吡洛芬似乎能够减缓某些骨关节炎实验模型的病情发展。这种作用的机制尚不清楚。
