对53个青少年胰岛素依赖型糖尿病（I.D.D.）家庭的HLA单倍型研究。
HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.
作者信息
Contu L, Deschamps I, Lestradet H, Hors J, Schmid M, Busson M, Benajam A, Marcelli-Barge A, Dausset J
出版信息
Tissue Antigens. 1982 Aug;20(2):123-40. doi: 10.1111/j.1399-0039.1982.tb00335.x.
R4 heterozygotes was observed. By contrast, the observed frequency of patients homozygous for DR3 or DR4 was not increased, but even slightly decreased. The data support a model of inheritance comprising at least two closely linked specifically "diabetic" loci (most of the time marked by B18, BfF1, DR3 and B15, BfS, DR4) and a non-specifically "diabetic" haplotype favouring auto-immunisation (most of the time marked by B8, BfS, DR3). This model is discussed in the light of the presented data and of those of the literature.
观察到R4杂合子。相比之下，DR3或DR4纯合患者的观察频率并未增加，甚至略有下降。数据支持一种遗传模型，该模型包括至少两个紧密连锁的特异性“糖尿病”基因座（大多数情况下由B18、BfF1、DR3以及B15、BfS、DR4标记）和一种有利于自身免疫的非特异性“糖尿病”单倍型（大多数情况下由B8、BfS、DR3标记）。根据所呈现的数据以及文献中的数据对该模型进行了讨论。
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