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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Colombo T, Broggini M, Gescher A, D'Incalci M

Xenobiotica. 1982 May;12(5):315-21. doi: 10.3109/00498258209052471.

In the rat 40% of a dose of 25 mg/kg of hexamethylmelamine or pentamethylmelamine was excreted in the urine as metabolites, more than 95% of which were N2N4-dimethylmelamine and monomethylmelamine. 2. Biliary excretion of hexamethylmelamine or pentamethylmelamine and their N-demethylated metabolites accounted for less than 2% of the administered dose. Only 0 X 3% was excreted with the faeces, suggesting that there is intestinal reabsorption of a portion of the methylmelamines passing into the bile. 3. Conjugates of methylmelamines with glucuronic acid or sulphate were found only in minute quantities in the urine or bile of rats treated with hexamethylmelamine or pentamethylmelamine. However a conjugation product of pentamethylmelamine, of as yet unknown nature, is a major metabolite after pentamethylmelamine treatment.

在大鼠中，25毫克/千克剂量的六甲基三聚氰胺或五甲基三聚氰胺有40%以代谢物形式经尿液排出，其中超过95%是N2N4 - 二甲基三聚氰胺和单甲基三聚氰胺。2. 六甲基三聚氰胺或五甲基三聚氰胺及其N - 去甲基代谢物的胆汁排泄量占给药剂量的比例不到2%。只有0.3%随粪便排出，这表明进入胆汁的部分甲基三聚氰胺存在肠重吸收现象。3. 在经六甲基三聚氰胺或五甲基三聚氰胺处理的大鼠的尿液或胆汁中，仅发现极少量的甲基三聚氰胺与葡萄糖醛酸或硫酸盐的结合物。然而，五甲基三聚氰胺的一种性质尚不清楚的结合产物是五甲基三聚氰胺处理后的主要代谢物。

Colombo T, Broggini M, Gescher A, D'Incalci M

Xenobiotica. 1982 May;12(5):315-21. doi: 10.3109/00498258209052471.

In the rat 40% of a dose of 25 mg/kg of hexamethylmelamine or pentamethylmelamine was excreted in the urine as metabolites, more than 95% of which were N2N4-dimethylmelamine and monomethylmelamine. 2. Biliary excretion of hexamethylmelamine or pentamethylmelamine and their N-demethylated metabolites accounted for less than 2% of the administered dose. Only 0 X 3% was excreted with the faeces, suggesting that there is intestinal reabsorption of a portion of the methylmelamines passing into the bile. 3. Conjugates of methylmelamines with glucuronic acid or sulphate were found only in minute quantities in the urine or bile of rats treated with hexamethylmelamine or pentamethylmelamine. However a conjugation product of pentamethylmelamine, of as yet unknown nature, is a major metabolite after pentamethylmelamine treatment.

在大鼠中，25毫克/千克剂量的六甲基三聚氰胺或五甲基三聚氰胺有40%以代谢物形式经尿液排出，其中超过95%是N2N4 - 二甲基三聚氰胺和单甲基三聚氰胺。2. 六甲基三聚氰胺或五甲基三聚氰胺及其N - 去甲基代谢物的胆汁排泄量占给药剂量的比例不到2%。只有0.3%随粪便排出，这表明进入胆汁的部分甲基三聚氰胺存在肠重吸收现象。3. 在经六甲基三聚氰胺或五甲基三聚氰胺处理的大鼠的尿液或胆汁中，仅发现极少量的甲基三聚氰胺与葡萄糖醛酸或硫酸盐的结合物。然而，五甲基三聚氰胺的一种性质尚不清楚的结合产物是五甲基三聚氰胺处理后的主要代谢物。