Grossman S A, Trump D L, Chen D C, Thompson G, Camargo E E
Am J Med. 1982 Nov;73(5):641-7. doi: 10.1016/0002-9343(82)90404-1.
Cerebrospinal fluid flow dynamics were evaluated by 111Indium-diethylenetriamine pentaacetic acid (111In-DTPA) ventriculography in 27 patients with neoplastic meningitis. Nineteen patients (70 percent) had evidence of cerebrospinal fluid flow disturbances. These occurred as ventricular outlet obstructions, abnormalities of flow in the spinal canal, or flow distrubances over the cortical convexities. Tumor histology, physical examination, cerebrospinal fluid analysis, myelograms, and computerized axial tomographic scans were not sufficient to predict cerebrospinal fluid flow patterns. These data indicate that cerebrospinal fluid flow abnormalities are common in patients with neoplastic meningitis and that 111In-DTPA cerebrospinal fluid flow imaging is useful in characterizing these abnormalities. This technique provides insight into the distribution of intraventricularly administered chemotherapy and may provide explanations for treatment failure and drug-induced neurotoxicity in patients with neoplastic meningitis.
采用铟-111标记的二乙三胺五乙酸（111In-DTPA）脑室造影术对27例肿瘤性脑膜炎患者的脑脊液流动动力学进行了评估。19例患者（70%）有脑脊液流动障碍的证据。这些障碍表现为脑室出口梗阻、椎管内血流异常或皮质凸面血流紊乱。肿瘤组织学、体格检查、脑脊液分析、脊髓造影和计算机断层扫描不足以预测脑脊液流动模式。这些数据表明，脑脊液流动异常在肿瘤性脑膜炎患者中很常见，111In-DTPA脑脊液流动成像有助于表征这些异常。该技术有助于深入了解脑室内化疗药物的分布情况，并可能为肿瘤性脑膜炎患者的治疗失败和药物性神经毒性提供解释。
