Fouron J C, Lapointe J, Letarte J, Bourgin J H, Ducharme G, Dussault J H, Davignon A
Arch Mal Coeur Vaiss. 1982 Aug;75(8):837-43.
Twelve infants, average age 5, 4 weeks (range 3 to 8 weeks) with congenital hypothyroidism were studied. In addition to routine evaluation including plasma T3, T4 and TSH estimation and the establishment of a clinical index of hypothyroidism on electrocardiogram and an echocardiogram were performed. The following variables were analysed: heart rate, QRS axis in the frontal plane, PR interval in Lead II, corrected QT interval in V5, amplitude of the P waves in Lead II, R waves in V3R, V1, V5 and V6; S waves in V1, V2 and V4 and T wave in V6. The ventricular activation time in V5 and QRS duration in V3R, V1 and V6 were also measured. The presence of pericardial effusion, left ventricular posterior wall and septal thickness, and left ventricular internal diastolic and systolic dimensions were determined by echocardiography. The following conclusions were drawn: 1. The ECG of hypothyroidism in the neonatal period is characterised by the low amplitude of the left ventricular potentials while increased conduction times were much less evident; 2. Only the sum of R + S in V2, the amplitude of the T wave in V6 and increase in QRS duration in V3R were influenced by severity of hypothyroidism; 3. Left ventricular microvoltage is not due to pericardial effusion which was absent in all our cases.
对12名先天性甲状腺功能减退症婴儿进行了研究，这些婴儿的平均年龄为5.4周（范围为3至8周）。除了包括血浆T3、T4和TSH测定在内的常规评估外，还进行了心电图和超声心动图检查以建立甲状腺功能减退症的临床指标。分析了以下变量：心率、额面QRS轴、II导联PR间期、V5导联校正QT间期、II导联P波振幅、V3R、V1、V5和V6导联R波；V1、V2和V4导联S波以及V6导联T波。还测量了V5导联心室激动时间以及V3R、V1和V6导联QRS时限。通过超声心动图确定心包积液的存在、左心室后壁和室间隔厚度以及左心室内径舒张期和收缩期大小。得出以下结论：1.新生儿期甲状腺功能减退症的心电图特征是左心室电位振幅低，而传导时间延长则不太明显；2.只有V2导联R + S总和、V6导联T波振幅以及V3R导联QRS时限增加受甲状腺功能减退症严重程度影响；3.左心室低电压并非由心包积液引起，我们所有病例均未出现心包积液。
