Galligan J P, Winship J, van Doorn T, Mortimer R H
Aust N Z J Med. 1982 Aug;12(4):248-54. doi: 10.1111/j.1445-5994.1982.tb03805.x.
Serum thyroglobulin levels were measured by a sensitive radioimmunoassay in 76 patients whose differentiated thyroid carcinoma had been treated by surgery with or without subsequent administration of radioactive iodine (131I). Examination of the results of 105 concomitant whole body 131I scan results and serum thyroglobulin levels showed a high degree (83.8%) of concordance between these two techniques. A significant correlation (r = 0.670, p less than 0.001) was found between serum thyroglobulin levels and quantitative 131I uptake in the neck and/or metastases in 42 patients in whom this was measured. Although a high degree of congruence was found between the results of 131I scans and the presence or absence of circulating thyroglobulin, 13 patients with negative scans using conventional doses of 131I had measurable levels of thyroglobulin. Eight of these patients had or subsequently developed evidence of residual thyroid tissue or metastatic carcinoma. The measurement of serum thyroglobulin levels in patients previously treated for differentiated carcinoma offers a more convenient and more sensitive method of detecting residual normal or neoplastic thyroid tissue than does whole body scanning in 131I.
采用灵敏的放射免疫分析法对76例分化型甲状腺癌患者的血清甲状腺球蛋白水平进行了检测，这些患者均接受了手术治疗，部分患者术后还接受了放射性碘（131I）治疗。对105例患者同时进行的全身131I扫描结果和血清甲状腺球蛋白水平分析显示，这两种技术之间具有高度一致性（83.8%）。在42例可检测颈部和/或转移灶131I摄取量的患者中，血清甲状腺球蛋白水平与定量131I摄取量之间存在显著相关性（r = 0.670，p < 0.001）。虽然131I扫描结果与循环甲状腺球蛋白的有无之间具有高度一致性，但13例使用常规剂量131I扫描结果为阴性的患者血清甲状腺球蛋白水平可检测到。其中8例患者存在或随后出现残余甲状腺组织或转移癌的证据。对于既往接受过分化型癌治疗的患者，检测血清甲状腺球蛋白水平比131I全身扫描提供了一种更方便、更灵敏的方法来检测残余的正常或肿瘤性甲状腺组织。
