霍奇金病的性腺功能：化疗的长期随访
Gonadal function in Hodgkin's disease: long-term follow-up of chemotherapy.
作者信息
Waxman J H, Terry Y A, Wrigley P F, Malpas J S, Rees L H, Besser G M, Lister T A
出版信息
Br Med J (Clin Res Ed). 1982 Dec 4;285(6355):1612-3. doi: 10.1136/bmj.285.6355.1612.
Abstract
A long-term study of gonadal function was conducted in 46 men and 28 women in prolonged remission of advanced Hodgkin's disease after cyclical combination chemotherapy with nitrogen mustard, vinblastine, prednisolone, and procarbazine. The mean follow-up was 6.9 years. Azoospermia or profound oligospermia occurred in 36 of the men, but late recovery was occasionally observed. Testosterone secretion was preserved. Amenorrhoea and gonadal hormone deficiency developed in 22 of the women and never recovered. Partial or complete chemical sterilisation and gonadal hormone deficiency is currently a consequence of cure of advanced Hodgkin's disease in most patients.
摘要
对46名男性和28名女性进行了一项关于性腺功能的长期研究，这些患者在接受了氮芥、长春碱、泼尼松龙和丙卡巴肼的周期性联合化疗后，处于晚期霍奇金淋巴瘤的长期缓解期。平均随访时间为6.9年。36名男性出现无精子症或严重少精子症，但偶尔观察到后期恢复。睾酮分泌得以保留。22名女性出现闭经和性腺激素缺乏，且从未恢复。部分或完全化学绝育以及性腺激素缺乏目前是大多数晚期霍奇金淋巴瘤患者治愈后的一个后果。
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