小鼠骨骼中血流、骨结构与239Pu沉积之间的关系。

Relationship between blood flow, bone structure, and 239Pu deposition in the mouse skeleton.

作者信息

Humphreys E R, Green D, Howells G R, Thorne M C

出版信息

Calcif Tissue Int. 1982 Jul;34(4):416-21. doi: 10.1007/BF02411277.

Abstract

The rate at which blood is supplied to several bones in female CBA mice was calculated from 18F measurements in bone and blood. Blood flow measurements were compared with plutonium uptake in whole bone and on endosteal and periosteal bone surfaces. The results showed that: (a) the rate at which blood is supplied to bone determines the rate of deposition of plutonium; (b) there is a threshold rate of blood supply below which plutonium is not deposited; and (c) the rate of blood supply determines the density of plutonium deposition on endosteal but not no periosteal bone surfaces. These results are discussed in the light of the current bone blood supply hypotheses.

摘要

通过对雌性CBA小鼠的骨骼和血液进行¹⁸F测量，计算出了血液供应至几块骨骼的速率。将血流量测量结果与全骨以及骨内膜和骨膜骨表面的钚摄取量进行了比较。结果表明：(a) 血液供应至骨骼的速率决定了钚的沉积速率；(b) 存在一个血液供应阈值，低于该阈值钚不会沉积；(c) 血液供应速率决定了钚在骨内膜而非骨膜骨表面的沉积密度。根据当前的骨血液供应假说对这些结果进行了讨论。