Johnson W K, Mauderly J L, Hahn F F, Muggenburg B A
J Toxicol Environ Health. 1982 Aug;10(2):201-21. doi: 10.1080/15287398209530244.
The relationship between respiratory function and morphological changes in 10 dogs exposed for 6 h to 69 ppm nitrogen dioxide was studied. Two additional dogs served as controls. Functional assessments included breathing pattern, breathing mechanics, forced expiration, gas exchange, and acid-base status. Gross, microscopic, and ultrastructural evaluations were made of lung tissues from dogs killed at 0.1, 1.0, 2.0, 3.0, 7.0 and 14.0 d after exposure. Functional changes were similar to those reported for man. The principal dysfunction was gas-exchange impairment, apparently resulting from foam in the airways. Breathing-pattern alterations appeared to result from stimulation of neural receptors. Gas-exchange measurements provided the most useful indicators of the pulmonary damage observed in this study.
研究了10只暴露于69 ppm二氧化氮6小时的犬的呼吸功能与形态学变化之间的关系。另外两只犬作为对照。功能评估包括呼吸模式、呼吸力学、用力呼气、气体交换和酸碱状态。对暴露后0.1、1.0、2.0、3.0、7.0和14.0天处死的犬的肺组织进行大体、显微镜和超微结构评估。功能变化与报道的人类情况相似。主要功能障碍是气体交换受损，显然是由气道中的泡沫引起的。呼吸模式改变似乎是由神经感受器受刺激所致。气体交换测量提供了本研究中观察到的肺损伤最有用的指标。
