Goldstein D J, Pitterman A B, Frech M, Kelly G, Pisano J J, Keiser H R
Life Sci. 1982 Jul 26;31(4):341-5. doi: 10.1016/0024-3205(82)90413-1.
The hypotension induced in the pentobarbital anesthesized rat by the i.v. administration of an active Hageman factor fragment (Hff) is significantly attenuated by naloxone. This effect is specific because the opiate antagonist does not modify the hypotension elicited by rat urinary kallikrein, bradykinin or nitroglycerin. These results suggest that the contact activation of endogenous Hageman factor could result in the generation of vasoactive opioid peptides derived from circulating large molecular weight precursors.
静脉注射活性Hageman因子片段（Hff）在戊巴比妥麻醉的大鼠中诱导的低血压被纳洛酮显著减弱。这种作用是特异性的，因为阿片拮抗剂不会改变大鼠尿激肽释放酶、缓激肽或硝酸甘油引起的低血压。这些结果表明，内源性Hageman因子的接触激活可能导致从循环的大分子前体衍生的血管活性阿片肽的产生。
