Weisinger R S, Denton D A, McKinley M J
J Comp Physiol Psychol. 1978 Jun;92(3):522-31. doi: 10.1037/h0077488.
The time delay that occurs between a rapid, systemically produced change in Na balance and a change of voluntary Na intake was examined in Na-deficient sheep with a parotid fistula. They were trained to bar press in order to replace a daily Na deficit of 300--500 mmol. During basal conditions on different days, each delivery to a drinking cup consisted of either a small or a large amount of NaHCO3 solution. In the experimental situation, the small amount of NaHCO3 was delivered to the cup, but total Na delivered was made to equal that of the large amount by automatic concurrent infusion of hypertonic NaCl intravenously with each delivery to the cup. As a control, the concurrent intravenous infusion was .15 M NaCl, which had little influence on Na balance. A significant difference in the cumulative number of deliveries between the hypertonic and isotonic NaCl infusion conditions occurred by 10--20 min. It is concluded that systemic injections of hypertonic NaCl are effective within 10 to 20 min in reducing the sodium appetite of Na-depleted animals.
在患有腮腺瘘管的缺钠绵羊中，研究了钠平衡快速系统性变化与自愿钠摄入量变化之间出现的时间延迟。训练它们按压杠杆以补充每天300 - 500毫摩尔的钠缺乏量。在不同日子的基础条件下，每次向饮水杯输送的液体要么是少量的碳酸氢钠溶液，要么是大量的碳酸氢钠溶液。在实验情况下，向杯中输送少量碳酸氢钠，但通过每次向杯中输送时静脉自动同时输注高渗氯化钠，使总输送钠量等于大量碳酸氢钠溶液中的钠量。作为对照，同时静脉输注的是0.15M氯化钠，其对钠平衡影响很小。在高渗和等渗氯化钠输注条件下，累积输送次数在10 - 20分钟时出现显著差异。得出的结论是，静脉注射高渗氯化钠在10至20分钟内可有效降低缺钠动物的钠食欲。
