Meng W, Meng S, Hampel R, Ventz M, Zeisler A
Z Gesamte Inn Med. 1982 Aug 15;37(16):540-2.
2,191 patients with bland struma were treated with tri-iodothyronine and a mixed preparation (thyreotom) for at least 2 years. Several clinical criteria were used for judgement. A good result could be obtained in 78.3 to 51.2% depending on the size of the struma (I-III). While in diffuse strumata good results were obtained in 87.8 to 69.0%, in nodular goitres we were successful only in 52.0-32.9%. The therapy may be successful at every age. Since with growing age the nodular goitres prevail, the chances of success become smaller. For the same reason there is a close correlation between age of the goitre and the therapeutic effect. The rate of success continuously decreases with growing age of the goitre. From this results that the therapy in goitre must begin early, before nodular and regressive changes, respectively, render the treatment difficult or render an acceptable result difficult.
2191例单纯性甲状腺肿患者接受了三碘甲状腺原氨酸和一种混合制剂（甲状腺片）治疗，疗程至少2年。采用了多项临床标准进行判断。根据甲状腺肿的大小（I - III级），良好疗效的比例在78.3%至51.2%之间。弥漫性甲状腺肿的良好疗效比例为87.8%至69.0%，而结节性甲状腺肿的成功治疗比例仅为52.0% - 32.9%。该疗法在各个年龄段都可能成功。由于随着年龄增长结节性甲状腺肿更为常见，成功的机会就变小了。出于同样的原因，甲状腺肿的年龄与治疗效果之间存在密切关联。随着甲状腺肿年龄的增长，成功的比例持续下降。由此得出结论，甲状腺肿的治疗必须尽早开始，分别在出现结节性和退行性改变之前，以免使治疗变得困难或难以获得可接受的结果。
