Jyssum K, Allunans J
Acta Pathol Microbiol Immunol Scand B. 1982 Oct;90(5):335-40. doi: 10.1111/j.1699-0463.1982.tb00128.x.
A survey has been made of Neisseria meningitidis strains isolated from patients in order to determine the prevalence of diffusible growth inhibitory substances active against other meningococci. Three types of growth inhibitory activity could be distinguished. The first type was release in cultures of nearly all strains after treatment with chloroform vapour. This activity inhibited all meningococci tested, including the donor strains. The properties were similar to those of the non-specific growth inhibitors observed among most strains of N. gonorrhoeae. The second type was demonstrated in cultures from four strains among 215 strains tested and may be present in a fifth strain. Bactericidal activity with high strain specificity was spontaneously released from cultures of the four strains. This type of activity was found to fit the description of a bacteriocin. The third type of inhibition was observed in one strain among the 215 strains tested. Cultures of this strain spontaneously released bacteriostatic activity. Products from the strain could inhibit almost all meningococcal strains except the donor strain itself. This activity was not entirely blocked by bovine serum albumin; it was not abolished by pronase and it was not stopped by dialysis membranes with cut-off 12000.
为了确定对其他脑膜炎球菌具有活性的可扩散生长抑制物质的流行情况，对从患者中分离出的脑膜炎奈瑟菌菌株进行了一项调查。可以区分出三种类型的生长抑制活性。第一种类型是几乎所有菌株在用氯仿蒸汽处理后的培养物中释放出来的。这种活性抑制了所有测试的脑膜炎球菌，包括供体菌株。其特性与在大多数淋病奈瑟菌菌株中观察到的非特异性生长抑制剂的特性相似。第二种类型在215株测试菌株中的4株培养物中得到证实，并且可能存在于第5株中。具有高菌株特异性的杀菌活性从这4株菌株的培养物中自发释放出来。发现这种活性类型符合细菌素的描述。在215株测试菌株中的1株中观察到第三种抑制类型。该菌株的培养物自发释放抑菌活性。该菌株的产物几乎可以抑制所有脑膜炎球菌菌株，但不包括供体菌株本身。这种活性不完全被牛血清白蛋白阻断；它不会被链霉蛋白酶消除，也不会被截留分子量为12000的透析膜阻止。
