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发育中大鼠肝脏内的糖原代谢酶活性

Glycogen metabolizing enzyme activities in the developing rat liver.

作者信息

Khandelwal R L

出版信息

Int J Biochem. 1982;14(12):1067-73. doi: 10.1016/0020-711x(82)90163-x.

DOI:10.1016/0020-711x(82)90163-x
PMID:6816641
Abstract
  1. The glycogen content of rat liver increased prenatally and dramatically decreased after the birth. 2. Glycogen synthase and glycogen phosphorylase activities increased prenatally, declined at 12 hr after birth and then again increased. 3. Phosphorylase kinase activities did not significantly change prenatally but steadily increased after the birth. 4. Protein kinase activities (units/mg liver) did not change prenatally but slightly increased after the birth. 5. Phosphoprotein phosphatase activities using phosphorylase a and histone as substrates dramatically increased at birth and then decreased after 24 hr of the birth.
摘要
  1. 大鼠肝脏的糖原含量在出生前增加,出生后显著下降。2. 糖原合酶和糖原磷酸化酶的活性在出生前增加,出生后12小时下降,然后再次增加。3. 磷酸化酶激酶的活性在出生前没有显著变化,但出生后稳步增加。4. 蛋白激酶活性(单位/毫克肝脏)在出生前没有变化,但出生后略有增加。5. 以磷酸化酶a和组蛋白为底物的磷蛋白磷酸酶活性在出生时急剧增加,出生后24小时后下降。

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