Tanaka Y, Katayama K, Tojo S
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Nov;34(11):1907-15.
The positive feedback function of the hypothalamo-pituitary system in aging women was investigated by means of intravenous injection of conjugated estrogens. Marked LH surge was observed in both sexually mature young (20-35 y.o.) and premenopausal (35-49 y.o.) women after the intravenous injection of 20mg of conjugated estrogens. However, merely a small LH surge was observed in postmenopausal climacteric (50-55 y.o.) women, and no LH surge in aged (over 56 y.o.) women. In the patients with hypergonadotropic hypogonadism who are in the same age as sexually mature women, no LH surge was induced by conjugated estrogens. But positive feedback test done after oral administration of conjugated estrogens (1.25 mg/day) for 14 days showed positive reaction in both the aged women and the patients with hypergonadotropic hypogonadism in whom no LH surge had been observed before estrogen priming. The present results suggest that the dysfunction of positive feedback in aged women is mainly due to the decreased levels of estrogen produced by the ovaries but not the primary organic or functional changes of the hypothalamus or the pituitary.
通过静脉注射结合雌激素，研究了衰老女性下丘脑 - 垂体系统的正反馈功能。在静脉注射20mg结合雌激素后，性成熟的年轻女性（20 - 35岁）和绝经前女性（35 - 49岁）均观察到明显的促黄体生成素（LH）高峰。然而，绝经后更年期女性（50 - 55岁）仅观察到小的LH高峰，而老年女性（56岁以上）未观察到LH高峰。在与性成熟女性年龄相同的高促性腺激素性性腺功能减退患者中，结合雌激素未诱导出LH高峰。但是，在口服结合雌激素（1.25mg/天）14天后进行的正反馈试验显示，在老年女性和高促性腺激素性性腺功能减退患者中均出现了阳性反应，这些患者在雌激素预处理前未观察到LH高峰。目前的结果表明，老年女性正反馈功能障碍主要是由于卵巢产生的雌激素水平降低，而非下丘脑或垂体的原发性器质性或功能性改变。
