Kryger P, Christoffersen P
Liver. 1982 Sep;2(3):200-6. doi: 10.1111/j.1600-0676.1982.tb00197.x.
Liver biopsies from a total of 240 patients with acute hepatitis A (86 patients), B (78 patients) and non-A, non-B (76 patients) were blindly evaluated for quantitative and qualitative light microscopic differences. No qualitative differences separate the three types of hepatitis, but the frequency and degree of some histological features seem to be characteristic of acute human non-A, non-B hepatitis. The degree of focal necrosis and portal inflammation was less pronounced in the non-A, non-B group as compared to the hepatitis A and B groups (P less than 0.01). Twenty-six percent of the non-A, non-B liver biopsies showed steatosis as compared with 10% and 6% in the hepatitis A and B groups, respectively (P less than 0.01). Bridging necrosis only occurred in liver biopsies from patients with non-A, non-B and B hepatitis. Abnormal bile ducts were detected in a total of five patients, three of whom were found in the non-A, non-B group. A comparison between histological findings in non-A, non-B patients with and without a possible intravenous exposure revealed that steatosis, cholestasis, large piecemeal necrosis and confluent necrosis occurred with the highest incidence in the patients without intravenous exposure, indicating that non-A, non-B hepatitis may be caused by more than one etiological agent.
对总共240例甲型（86例）、乙型（78例）和非甲非乙型（76例）急性肝炎患者的肝活检标本进行了盲法评估，以观察其在定量和定性光镜下的差异。三种类型的肝炎在定性上没有差异，但某些组织学特征的频率和程度似乎是人类急性非甲非乙型肝炎的特征。与甲型和乙型肝炎组相比，非甲非乙型组的局灶性坏死和门脉炎症程度较轻（P<0.01）。26%的非甲非乙型肝活检显示有脂肪变性，而甲型和乙型肝炎组分别为10%和6%（P<0.01）。桥接坏死仅发生在非甲非乙型和乙型肝炎患者的肝活检中。总共5例患者检测到胆管异常，其中3例在非甲非乙型组。对有或无静脉暴露可能性的非甲非乙型患者的组织学结果进行比较发现，脂肪变性、胆汁淤积、大片状坏死和融合性坏死在无静脉暴露的患者中发生率最高，这表明非甲非乙型肝炎可能由多种病因引起。
