Salem S A, King D J, McDevitt D G
Psychopharmacology (Berl). 1982;78(2):147-9. doi: 10.1007/BF00432253.
The effect of long-term treatment with flupenthixol on hepatic microsomal enzyme activity was studied in 12 chronic schizophrenic outpatients who had been receiving two weekly maintenance doses for at least 6 months. Antipyrine half-life was measured in the 12 patients while they continued to receive the drug. Flupenthixol was then discontinued for 6 weeks and antipyrine half-life was repeated in 7 of the 12 patients. In the 12 patients the plasma antipyrine elimination half-life was 4-24 h (mean 9.73 +/- 1.61 h) when receiving flupenthixol and there was a significant negative correlation between antipyrine half-life and the dose of flupenthixol (r = 0.582, P less than 0.05). In the seven patients to whom antipyrine was given on two occasions, antipyrine half-life was 7.33 +/- 1.07 h and 12.04 +/- 1.87 h on and off flupenthixol treatment respectively. The clearance significantly decreased when flupenthixol was discontinued, but there was no change in the apparent volume of distribution.
在12名慢性精神分裂症门诊患者中研究了氟哌噻吨长期治疗对肝微粒体酶活性的影响，这些患者已接受两周一次的维持剂量治疗至少6个月。在这12名患者继续接受药物治疗期间测定了安替比林半衰期。然后停用氟哌噻吨6周，并在12名患者中的7名患者中重复测定安替比林半衰期。在这12名患者中，接受氟哌噻吨治疗时血浆安替比林消除半衰期为4 - 24小时（平均9.73±1.61小时），安替比林半衰期与氟哌噻吨剂量之间存在显著负相关（r = 0.582，P < 0.05）。在7名接受两次安替比林给药的患者中，氟哌噻吨治疗期间和停药后安替比林半衰期分别为7.33±1.07小时和12.04±1.87小时。停用氟哌噻吨后清除率显著降低，但分布容积无变化。
