Zhukova L F, Ereshchenko V V
Zh Mikrobiol Epidemiol Immunobiol. 1982 Oct(10):65-8.
Antigenic relations between meningococci, serogroups Z and 29E, have been studied with the use of serological methods. The thermolabile fractions of meningococci belonging to the above serogroups have been shown to contain common antigenic determinants which ensure the presence of serological cross reactions. Cross-reacting precipitating and agglutinating antibodies can be completely removed by the adsorption of meningococcal antisera, serogroups Z and 29E, with the cultures of heterologous serogroups. In the antisera adsorbed by meningococci belonging to heterologous groups a decrease in the titers of agglutinins, hemagglutinins and precipitins, particularly pronounced in adsorbed serogroup 29E antisera, has been observed.
已采用血清学方法研究了血清群Z和29E脑膜炎球菌之间的抗原关系。已证明属于上述血清群的脑膜炎球菌的不耐热组分含有共同的抗原决定簇,这确保了血清学交叉反应的存在。通过用异源血清群的培养物吸附血清群Z和29E的脑膜炎球菌抗血清,可完全去除交叉反应性沉淀抗体和凝集抗体。在由异源群脑膜炎球菌吸附的抗血清中,已观察到凝集素、血凝素和沉淀素效价降低,在吸附的血清群29E抗血清中尤为明显。