The effect of dietary sodium chloride and gamma-glutamyl dopa on tubular necrosis following glycerol administration in the rat.

The protective effect of a high dietary sodium intake in models of acute renal failure is well known. This effect may be mediated an increased endogenous dopamine production. The effects of different salt intakes and υ-glutamyl dopa (a renal pro-drug for dopamine) on the histological changes following s.c. glycerol were studied in the rat. The protective effect on a high sodium diet was confirmed and υ-glutamyl dopa was also shown to reduce significantly the damage caused by glycerol.