Virelizier J L
Eur J Immunol. 1982 Nov;12(11):988-90. doi: 10.1002/eji.1830121119.
Spleen cells from mice of 6 different strains were stimulated with pokeweed mitogen and the amount of gamma interferon in th supernatants was measured. Three strains (BALB/c, A/J and C3H/He) were found to be low producers (less than 50 units) whereas three other strains (C57BL6, CBA and AKR) were high producers (50 to 500 units). F1 hybrids between a low producer strain (A/J) and a high producer strain (C57BL6) were found to produce low amounts of interferon. Nude mice did not produce detectable amounts of pokeweed mitogen-induce gamma interferon. The level of production of this T cell lymphokine is thus under genetic control.
用商陆丝裂原刺激6种不同品系小鼠的脾细胞，并测定上清液中γ干扰素的含量。发现三个品系（BALB/c、A/J和C3H/He）产生量低（少于50单位），而其他三个品系（C57BL6、CBA和AKR）产生量高（50至500单位）。发现低产生品系（A/J）和高产生品系（C57BL6）之间的F1杂种产生少量干扰素。裸鼠不产生可检测量的商陆丝裂原诱导的γ干扰素。因此，这种T细胞淋巴因子的产生水平受遗传控制。
