Ro 15 - 1788和丙基-β-咔啉可拮抗甲基-β-咔啉诱发的惊厥。

Methyl-beta-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-beta-carboline.

作者信息

Valin A, Dodd R H, Liston D R, Potier P, Rossier J

出版信息

Eur J Pharmacol. 1982 Nov 5;85(1):93-7. doi: 10.1016/0014-2999(82)90428-9.

Abstract

Injected i.v. into baboons, Ro 15-1788 (a benzodiazepine antagonist) and propyl-beta-carboline-3-carboxylate did not modify either the behavior or the electroencephalogram at doses up to 2 mg/kg. Methyl-beta-carboline-3-carboxylate is a potent convulsant at doses of 20 micrograms/kg in photosensitive baboons and 100 micrograms/kg in non-photosensitive baboons. These convulsive doses of methyl-beta-carboline-3-carboxylate are effectively antagonized by 0.5 mg/kg of Ro 15-1788 and also by 2 mg/kg of propyl-beta-carboline-3-carboxylate.

摘要

静脉注射到狒狒体内后，Ro 15 - 1788（一种苯二氮䓬拮抗剂）和丙基 - β - 咔啉 - 3 - 羧酸酯在剂量高达2毫克/千克时，对行为或脑电图均无影响。甲基 - β - 咔啉 - 3 - 羧酸酯在光敏狒狒中剂量为20微克/千克、在非光敏狒狒中剂量为100微克/千克时是一种强效惊厥剂。这些甲基 - β - 咔啉 - 3 - 羧酸酯的惊厥剂量可被0.5毫克/千克的Ro 15 - 1788以及2毫克/千克的丙基 - β - 咔啉 - 3 - 羧酸酯有效拮抗。