苯二氮䓬受体配体对印防己毒素和戊四氮诱发癫痫发作的双向作用。

Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.

作者信息

Jensen L H, Petersen E N

出版信息

J Neural Transm. 1983;58(3-4):183-91. doi: 10.1007/BF01252804.

PMID:6319592

Abstract

The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216. The BZ receptor antagonists ZK 93426 and Ro 15-1788 had no effect on the dose response curves. The anticonvulsive action of lorazepam and the proconvulsive action of DMCM against picrotoxin-induced seizures and against pentylenetetrazol-induced seizures was inhibited by low doses of ZK 93426 and Ro 15-1788. These results indicate that the bidirectional effects of benzodiazepine receptor ligands on picrotoxin and pentylenetetrazol induced seizures is actually mediated through benzodiazepine receptors.

摘要

印防己毒素诱发癫痫和戊四氮诱发癫痫的剂量反应曲线，被苯二氮䓬（BZ）受体激动剂劳拉西泮向右移动，而被反向激动剂DMCM、ZK 90886、FG 7142和CGS 8216向左移动。BZ受体拮抗剂ZK 93426和Ro 15 - 1788对剂量反应曲线无影响。低剂量的ZK 93426和Ro 15 - 1788可抑制劳拉西泮的抗惊厥作用以及DMCM对印防己毒素诱发癫痫和戊四氮诱发癫痫的促惊厥作用。这些结果表明，苯二氮䓬受体配体对印防己毒素和戊四氮诱发癫痫的双向作用实际上是通过苯二氮䓬受体介导的。