黑腹果蝇性别特异性致死基因的研究。IV. 对三个雄性特异性致死基因mle、msl-2(27)和mle(3)132的雌雄嵌合体分析。
Studies on the sex-specific lethals of Drosophila melanogaster. IV. Gynandromorph analysis of three male-specific lethals, mle, msl-2(27) and mle(3)132.
作者信息
Uenoyama T, Uchida S, Fukunaga A, Oishi K
出版信息
Genetics. 1982 Oct;102(2):223-31. doi: 10.1093/genetics/102.2.223.
Abstract
Mutants at three male-specific lethal loci of Drosophila melanogaster (mle, msl-2(27) and mle(3)132) were examined by gynandromorph analysis. In all cases only a very few gynandromorphs with small X/O patches appeared. Most of these small X/O patches were in the abdomen, and the structures in these X/O regions were reduced in size. These results indicate that the primary effects of these mutants are not on any particular organs or tissues, but rather on individual cells, mle and msl-2 have been shown by BELOTE and LUCCHESI (1980a) to be defective in dosage compensation in X/Y males. We suggest that this dosage-compensation defect results in the expression of Minute-like phenotypes in X/O cells, and hence results in the death of X/O males and flies with large X/O tissue areas.
摘要
通过雌雄嵌合体分析，对果蝇三个雄性特异性致死位点（mle、msl - 2(27)和mle(3)132）的突变体进行了检测。在所有情况下，仅出现了极少数带有小X/O斑块的雌雄嵌合体。这些小X/O斑块大多位于腹部，且这些X/O区域的结构尺寸减小。这些结果表明，这些突变体的主要作用并非针对任何特定器官或组织，而是针对单个细胞。BELOTE和LUCCHESI（1980a）已表明，mle和msl - 2在X/Y雄性的剂量补偿中存在缺陷。我们认为，这种剂量补偿缺陷导致X/O细胞中出现类微小体表型的表达，进而导致X/O雄性以及具有大面积X/O组织区域的果蝇死亡。
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