伊文思蓝染料对小鼠结核菌免疫的抑制作用。
Suppression of tuberculoimmunity in mice by Evans blue dye.
作者信息
Crowle A J, May M H
出版信息
Infect Immun. 1982 Dec;38(3):932-7. doi: 10.1128/iai.38.3.932-937.1982.
Evans blue dye, which acts as an adjuvant in mice to promote induction of cell-mediated immunity, was found earlier to apparently act contrarily and decrease tuberculoimmunity. This phenomenon was investigated here in a long-term experiment examining the persistence of the suppressed immunity. Systemic suppression after injection of only 1 mg of dye was confirmed and was found to last for more than 2 weeks but less than 11 weeks. Localized evidence for dye-caused depression of tuberculoimmunity also was seen by the development in dye-injected mice immunized with emulsified whole bacilli of caseating tubercles at sites of pulmonary infection, a very rare type of pathology for tuberculosis in mice. The experiment, in addition, detected an aging-related decline in mice of resistance to tuberculosis evident by shortened survival, enlarged pulmonary tubercles, and increased susceptibility to systemic tuberculin reaction.
伊文思蓝染料在小鼠中作为佐剂可促进细胞介导免疫的诱导，早期发现它显然起相反作用，会降低结核免疫。在此进行了一项长期实验来研究免疫抑制的持续性，对这一现象展开调查。证实仅注射1毫克染料后会出现全身抑制，且这种抑制持续超过2周但不到11周。在用乳化全菌免疫的注射染料小鼠的肺部感染部位出现干酪样结核结节（这在小鼠结核病中是一种非常罕见的病理类型），也可见到染料导致结核免疫抑制的局部证据。此外，该实验还检测到小鼠对结核病的抵抗力存在与衰老相关的下降，表现为存活期缩短、肺部结核结节增大以及对全身结核菌素反应的易感性增加。
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