Siriwatratananonta P, Sinsakul V, Stern K, Slavin R G
J Lab Clin Med. 1978 Sep;92(3):402-7.
Of uremic patients, 37% demonstrated the presence of CFI in their sera. The serum factor acts directly on leukotatic factors, C5f, C3f, and BF to render them irreversibly inactive. Inhibitory activity was found in five of 16 patients: 37% to 61% for C5f, 25% to 36% for C3f, and 28% to 51% for BF. There is no correlation of this inhibitory activity with BUN or creatinine levels. The presence of this chemotactic inhibitor may be responsible for the increased incidence of infection in uremia.
在尿毒症患者中，37%的患者血清中存在趋化因子抑制剂（CFI）。该血清因子直接作用于趋化因子C5f、C3f和B因子（BF），使其不可逆地失活。在16例患者中有5例发现了抑制活性：对C5f的抑制率为37%至61%，对C3f为25%至36%，对BF为28%至51%。这种抑制活性与血尿素氮（BUN）或肌酐水平无关。这种趋化抑制剂的存在可能是尿毒症患者感染发生率增加的原因。
