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[中度蛋白质缺乏对雌性大鼠繁殖及幼崽断奶前发育的影响]

[Effect of moderate protein deficiency on reproduction in the female rat and on the development of the pups until weaning].

作者信息

Beck B, Dollet J M, Max J P, Debry G

出版信息

Reprod Nutr Dev (1980). 1982;22(5):841-9.

PMID:6818645
Abstract

Two groups of Wistar female rats were respectively fed ad libitum a standard stock diet containing 22 p. 100 protein (n = 93) and a diet containing 7.5 p. 100 protein (n = 189) for 8 weeks. They were mated with male rats of the same strain after 2 weeks of these diets. A small decrease (8 p. 100) in fecundity was observed but this moderate protein deprivation did not affect either the litter size (9.68 +/- 3.50 vs 9.61 +/- 3.69) or the percentage of stillborn pups (4.8 vs 4.9 p. 100). The postnatal mortality of the pups of deprived dams was much higher than that of pups from normal dams (11.2 vs 0.9 p. 100). During the suckling period, the 7.5 p. 100 protein diet did not cover the requirements of the dams. They lost 20 p. 100 of their weight, whereas the weight of the dams fed the 22 p. 100 protein diet remained stable. The weight deficit of the young rats born from deprived dams was about 10 p. 100 at birth but it rose to 50 p. 100 at weaning. During the gestation and suckling periods, the maternal body stores and tissues were mobilized to assure the growth of the young.

摘要

将两组雌性Wistar大鼠分别随意喂食含22%蛋白质的标准储备日粮(n = 93)和含7.5%蛋白质的日粮(n = 189),持续8周。在这些日粮喂养2周后,它们与同品系的雄性大鼠交配。观察到繁殖力有小幅下降(8%),但这种适度的蛋白质缺乏对窝仔数(9.68±3.50对9.61±3.69)或死产仔鼠百分比(4.8%对4.9%)均无影响。蛋白质缺乏的母鼠所产幼崽的产后死亡率远高于正常母鼠所产幼崽(11.2%对0.9%)。在哺乳期,含7.5%蛋白质的日粮无法满足母鼠的需求。它们体重减轻了20%,而喂食含22%蛋白质日粮的母鼠体重保持稳定。蛋白质缺乏的母鼠所产幼鼠出生时体重不足约10%,但到断奶时升至50%。在妊娠和哺乳期,母鼠的身体储备和组织被调动起来以确保幼崽的生长。

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