NZB×NZW小鼠中狼疮性肾炎的三个基因。
Three genes for lupus nephritis in NZB x NZW mice.
作者信息
Knight J G, Adams D D
出版信息
J Exp Med. 1978 Jun 1;147(6):1653-60. doi: 10.1084/jem.147.6.1653.
Abstract
The occurrence of early severe lupus nephritis in (NZB x NZW)F1 mice must depend on the action of at least two dominant or codominant genes (at least one gene from each parent) as neither of the inbred parental strains shows the disorder. Identifying affected animals by antemortem determinations of renal function, we have studied the incidence of the renal disease in 230 (NZB x NZW) x NZW backcross mice (an earlier study) and, in this study, in 150 (NZB x NZW) x NZB backcross mice. The data indicate that the NZB strain contributes only one gene and the NZW strain contributes two genes, or clusters of closely linked genes, to the renal disorder of the F1 hybrid. One of the NZW genes was found to be linked to the H-2 complex. All three genes must be dominant or codominant, as their effect is expressed in the heterozygous state.
摘要
（NZB×NZW）F1小鼠早期严重狼疮性肾炎的发生必定依赖于至少两个显性或共显性基因的作用（每个亲本至少提供一个基因），因为两个近交亲本品系均未表现出这种病症。通过生前肾功能测定来识别患病动物，我们在230只（NZB×NZW）×NZW回交小鼠中（早期研究）以及在本研究中的150只（NZB×NZW）×NZB回交小鼠中研究了肾病的发病率。数据表明，NZB品系仅贡献一个基因，而NZW品系为F1杂种的肾脏疾病贡献两个基因或紧密连锁的基因簇。发现其中一个NZW基因与H-2复合体连锁。所有这三个基因必定是显性或共显性的，因为它们的作用在杂合状态下就会表现出来。
相似文献
1
Three genes for lupus nephritis in NZB x NZW mice.NZB×NZW小鼠中狼疮性肾炎的三个基因。
J Exp Med. 1978 Jun 1;147(6):1653-60. doi: 10.1084/jem.147.6.1653.
2
The genetic contribution of the NZB mouse to the renal disease of the NZB x NZW hybrid.NZB小鼠对NZB×NZW杂交种肾脏疾病的遗传贡献。
Clin Exp Immunol. 1977 May;28(2):352-8.
3
4
The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.新西兰白兔（NZW）基因对（新西兰黑兔×新西兰白兔）F1代小鼠狼疮样疾病的影响。
J Exp Med. 1987 May 1;165(5):1237-51. doi: 10.1084/jem.165.5.1237.
5
Genetic studies of autoimmunity in New Zealand mice. IV. Contribution of NZB and NZW genes to the spontaneous occurrence of retroviral gp70 immune complexes in (NZB X NZW)F1 hybrid and the correlation to renal disease.新西兰小鼠自身免疫的遗传学研究。IV. NZB和NZW基因对（NZB×NZW）F1杂种中逆转录病毒gp70免疫复合物自发出现的贡献及其与肾脏疾病的相关性。
J Immunol. 1983 Feb;130(2):740-6.
6
Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE).剖析肿瘤坏死因子-α及主要组织相容性复合体（MHC）内II类基因多态性对小鼠系统性红斑狼疮（SLE）的影响。
Int Immunol. 1998 Oct;10(10):1467-72. doi: 10.1093/intimm/10.10.1467.
7
Genetic association between natural autoantibody responses to histones and DNA in murine lupus.小鼠狼疮中针对组蛋白和DNA的天然自身抗体反应之间的遗传关联。
Autoimmunity. 1992;12(4):285-93. doi: 10.3109/08916939209148471.
8
Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW)F1 mice.将新西兰黑鼠（NZB）中一个与高球蛋白血症相关的基因定位到4号染色体的远端区域，以及该基因对（NZB×NZW）F1小鼠系统性红斑狼疮的影响。
Int Immunol. 1994 Dec;6(12):1857-64. doi: 10.1093/intimm/6.12.1857.
9
Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus.对单独致病性自身抗体反应的控制标志着主要组织相容性复合体（MHC）基因对小鼠狼疮的影响。
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8098-103. doi: 10.1073/pnas.96.14.8098.
10
A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F1 hybrid mouse model of systemic lupus erythematosus.在系统性红斑狼疮的（新西兰黑鼠×新西兰白鼠）F1杂交小鼠模型中，2号染色体上的一个新的易感基因座。
J Immunol. 2002 Mar 15;168(6):3042-9. doi: 10.4049/jimmunol.168.6.3042.
引用本文的文献
1
Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus.氧化应激作为自身免疫性溶血性贫血和系统性红斑狼疮的潜在致病因素。
World J Nephrol. 2015 May 6;4(2):213-22. doi: 10.5527/wjn.v4.i2.213.
2
Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus.系统性红斑狼疮中疾病和发病机制的偶然性、遗传学及异质性
Semin Immunopathol. 2014 Sep;36(5):495-517. doi: 10.1007/s00281-014-0440-x. Epub 2014 Aug 8.
3
The autoimmune model of schizophrenia.精神分裂症的自身免疫模型。
ISRN Psychiatry. 2012 Apr 30;2012:758072. doi: 10.5402/2012/758072. Print 2012.
4
Significance of MHC class II haplotypes and IgG Fc receptors in SLE.MHC II类单倍型和IgG Fc受体在系统性红斑狼疮中的意义。
Springer Semin Immunopathol. 2006 Oct;28(2):163-74. doi: 10.1007/s00281-006-0036-1. Epub 2006 Sep 14.
5
Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.利用基因内重组研究MHC II类A和E基因在小鼠狼疮模型自身免疫易感性中的作用。
Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13838-43. doi: 10.1073/pnas.0405807101. Epub 2004 Sep 10.
6
New Zealand mixed mice: a genetic systemic lupus erythematosus model for assessing environmental effects.新西兰混合小鼠：一种用于评估环境影响的遗传性系统性红斑狼疮模型。
Environ Health Perspect. 1999 Oct;107 Suppl 5(Suppl 5):713-21. doi: 10.1289/ehp.99107s5713.
7
Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus.对单独致病性自身抗体反应的控制标志着主要组织相容性复合体（MHC）基因对小鼠狼疮的影响。
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8098-103. doi: 10.1073/pnas.96.14.8098.
8
Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW)F1 mice.NZB和NZW小鼠的内在B细胞缺陷导致了（NZB×NZW）F1小鼠患系统性红斑狼疮。
J Exp Med. 1996 Sep 1;184(3):853-61. doi: 10.1084/jem.184.3.853.
9
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
J Clin Invest. 1994 Jan;93(1):56-62. doi: 10.1172/JCI116984.
10
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.通过腺病毒介导的基因转移对肿瘤坏死因子活性进行长期有效的阻断。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):215-9. doi: 10.1073/pnas.91.1.215.
本文引用的文献
1
AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS.NZB/BL小鼠的自身免疫性疾病。I. 自发性肾小球肾炎模型系统的病理学与发病机制
J Exp Med. 1965 Jul 1;122(1):25-40. doi: 10.1084/jem.122.1.25.
2
RENAL IMMUNOFLUORESCENCE IN NZB-NZW MICE.NZB-NZW小鼠的肾脏免疫荧光
Nature. 1964 Sep 5;203:1080-1. doi: 10.1038/2031080a0.
3
ANTINUCLEAR FACTOR IN MICE.小鼠中的抗核因子。
J Immunol. 1964 Jul;93:148-54.
4
Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice.与小鼠杂交品系中狼疮红斑试验阳性相关的肾脏疾病
Nature. 1963 Jan 12;197:197. doi: 10.1038/197197a0.
5
A new red-cell autoantibody in NZB mice.
Nature. 1965 Aug 7;207(997):601-4. doi: 10.1038/207601a0.
6
7
Autoantibodies and nephritis in the white strain (NZW) of New Zealand mice.新西兰小鼠白色品系（NZW）中的自身抗体与肾炎
Arthritis Rheum. 1969 Aug;12(4):355-64. doi: 10.1002/art.1780120403.
8
Spontaneous hydronephrosis in the inbred mouse strain NZC.
Aust J Exp Biol Med Sci. 1971 Oct;49(5):477-86. doi: 10.1038/icb.1971.51.
9
Evidence that autoimmune renal disease and tumour formation in NZB-W mice are due to separate defects.有证据表明，NZB-W小鼠的自身免疫性肾病和肿瘤形成是由不同的缺陷引起的。
Clin Exp Immunol. 1972 Aug;11(4):565-8.
10
Failure to transfer haemolytic anaemia or glomerulonephritis with cell-free material from NZB mice.未能用新西兰黑鼠的无细胞物质转移溶血性贫血或肾小球肾炎。
Clin Exp Immunol. 1970 Feb;6(2):227-39.
Zotero 插件