NZB×NZW小鼠中狼疮性肾炎的三个基因。
Three genes for lupus nephritis in NZB x NZW mice.
作者信息
Knight J G, Adams D D
出版信息
J Exp Med. 1978 Jun 1;147(6):1653-60. doi: 10.1084/jem.147.6.1653.
Abstract
The occurrence of early severe lupus nephritis in (NZB x NZW)F1 mice must depend on the action of at least two dominant or codominant genes (at least one gene from each parent) as neither of the inbred parental strains shows the disorder. Identifying affected animals by antemortem determinations of renal function, we have studied the incidence of the renal disease in 230 (NZB x NZW) x NZW backcross mice (an earlier study) and, in this study, in 150 (NZB x NZW) x NZB backcross mice. The data indicate that the NZB strain contributes only one gene and the NZW strain contributes two genes, or clusters of closely linked genes, to the renal disorder of the F1 hybrid. One of the NZW genes was found to be linked to the H-2 complex. All three genes must be dominant or codominant, as their effect is expressed in the heterozygous state.
摘要
（NZB×NZW）F1小鼠早期严重狼疮性肾炎的发生必定依赖于至少两个显性或共显性基因的作用（每个亲本至少提供一个基因），因为两个近交亲本品系均未表现出这种病症。通过生前肾功能测定来识别患病动物，我们在230只（NZB×NZW）×NZW回交小鼠中（早期研究）以及在本研究中的150只（NZB×NZW）×NZB回交小鼠中研究了肾病的发病率。数据表明，NZB品系仅贡献一个基因，而NZW品系为F1杂种的肾脏疾病贡献两个基因或紧密连锁的基因簇。发现其中一个NZW基因与H-2复合体连锁。所有这三个基因必定是显性或共显性的，因为它们的作用在杂合状态下就会表现出来。
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