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[多普勒超声心动图对主动脉瓣关闭不全的无创性研究]

[Non-invasive study of aortic insufficiency by Doppler echocardiography].

作者信息

Diebold B, Blanchard D, Nee M, Colonna G, Peronneau P, Guermonprez J L, Forman J, Sellier P, Maurice P

出版信息

Arch Mal Coeur Vaiss. 1982 Nov;75(11):1259-65.

PMID:6818916
Abstract

The possibilities of diagnosis and quantification of aortic regurgitation by pulsed Doppler analysis of blood flow in the aortic arch were examined in 60 patients aged between 9 and 67 years old. Aortic flow curves were recorded from the suprasternal area with the sample volume positioned at the junction of the horizontal part of the aortic arch and the descending aorta. Normal flow curves are characterised by an anterograde systolic wave with a brief proto-diastolic reflux. In aortic regurgitation holodiastolic reflux is observed. An index of regurgitation may be calculated from the ratio of the amplitude of end diastolic reflux measured on the R wave of th ECG and the maximal amplitude of anterograde systolic flow. This ratio eliminates the factor related to the incident angle between the ultrasound beam and the direction of blood flow. The values of this ratio were compared to the semi quantitative assessment of aortic regurgitation from ascending aortic angiography. The only false negatives were observed in patients with negligible regurgitation (grade I). One false positive result was obtained in a patient in whom it was difficult to obtain the recording and in whom the value of the ratio was very low (0,02). Global specificity was 91 p. 100 and sensitivity was 82 p. 100. The sensitivity for average or severe regurgitation was 100 p. 100. The correlation coefficient between the Doppler index or regurgitation and the semi quantitative angiographic estimation was 0,69. In patients with pure aortic regurgitation the correlation reached 0,85 (p less than 0,001). The differences between the different groups then became highly significant.

摘要

对60名年龄在9至67岁之间的患者进行了研究,通过对主动脉弓血流进行脉冲多普勒分析来诊断和量化主动脉瓣反流的可能性。从胸骨上区记录主动脉血流曲线,取样容积置于主动脉弓水平部与降主动脉交界处。正常血流曲线的特征是有一个正向收缩波和一个短暂的舒张前期反流。在主动脉瓣反流时可观察到全舒张期反流。反流指数可根据在心电图R波上测量的舒张末期反流幅度与正向收缩期血流最大幅度之比来计算。该比值消除了与超声束和血流方向之间入射角相关的因素。将该比值与升主动脉血管造影对主动脉瓣反流的半定量评估结果进行比较。仅在反流可忽略不计(I级)的患者中观察到假阴性结果。在一名难以获得记录且比值非常低(0.02)的患者中得到了一个假阳性结果。总体特异性为91%,敏感性为82%。对中度或重度反流的敏感性为100%。多普勒反流指数与血管造影半定量评估之间的相关系数为0.69。在单纯主动脉瓣反流患者中,相关性达到0.85(P<0.001)。不同组之间的差异随后变得非常显著。

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