中非共和国分离出的淋球菌的抗菌药敏性。
Antimicrobial susceptibility of gonococci isolated in the Central African Republic.
作者信息
Widy-Wirski R, D'Costa J, Biddle J, Brown S
出版信息
Bull World Health Organ. 1982;60(6):959-63.
Using agar dilution techniques, we determined the minimum inhibitory concentrations (MIC) of 11 antimicrobials for 70 isolates of Neisseria gonorrhoeae obtained in Bangui, Central African Republic. These gonococci were found to be fairly susceptible to commonly used antibiotics: only 3 isolates (4%) had a penicillin MIC >/= 1.0 mug/ml and 6 (9%) had a tetracycline MIC >/= 2.0 mug/ml. With regard to other antibiotics, 54 isolates (77%) had an erythromycin MIC >/= 0.25 mug/ml, all had a spectinomycin MIC </= 16 mug/ml, and 32 (46%) had a sulfamethoxazole/trimethoprim MIC >/= 9.5/0.5 mug/ml. None of these isolates produced penicillinase.This study has helped to provide a rational basis for establishing national gonorrhoea treatment recommendations in the Central African Republic.
采用琼脂稀释技术，我们测定了从中非共和国班吉获取的70株淋病奈瑟菌对11种抗菌药物的最低抑菌浓度（MIC）。这些淋球菌对常用抗生素相当敏感：仅3株（4%）青霉素MIC≥1.0μg/ml，6株（9%）四环素MIC≥2.0μg/ml。对于其他抗生素，54株（77%）红霉素MIC≥0.25μg/ml，所有菌株壮观霉素MIC≤16μg/ml，32株（46%）磺胺甲恶唑/甲氧苄啶MIC≥9.5/0.5μg/ml。这些菌株均不产青霉素酶。本研究有助于为中非共和国制定国家淋病治疗建议提供合理依据。
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