Ye S Z
National Center for STD Control and Research, Nanjing, People's Republic of China.
Sex Transm Dis. 1994 Jul-Aug;21(4):237-40.
The appearance and the endemic of penicillinase-producing Neisseria gonorrhoeae (PPNG) and other resistant strains cause much difficulty in the treatment of gonorrhea. To keep surveillance of the strains is important for the control of gonorrhea nationwide.
To know the resistance to antibiotics of Neisseria gonorrhoeae strains isolated in China.
The minimum inhibitory concentration (MIC) to penicillin, spectinomycin, and cephalosporins was determined by the agar plate dilution test in strains of N. gonorrhoeae submitted from six cities in various areas of the country during the period 1987-1992, and the prevalence of penicillinase-producing N. gonorrhoeae strains were examined by the rapid idometric method.
The resistant strains to penicillin (MIC > or = 1.0 microgram/ml) accounted for 57.5% of all isolates. The resistant strains to spectinomycin (MIC > or = 128 micrograms/ml) made up 1.3% and the strains which had a MIC closing resistance (MIC = 64 micrograms/ml) accounted for 4%. There were 18 PPNG strains (4.3%) in 419 isolates from Nanjing and Nanning city. The resistant strains to ceftrixone and cefotaxime accounted for 2.6% and 4.2%, respectively.
The situation of N. gonorrhoeae resistance to penicillin is rather serious in the country and relevant measures should be taken in the choice of therapeutic drugs, the follow-up of patients and the surveillance of gonorrhea.
产青霉素酶淋病奈瑟菌（PPNG）及其他耐药菌株的出现和流行给淋病治疗带来很大困难。对这些菌株进行监测对于全国范围内淋病的控制至关重要。
了解中国分离的淋病奈瑟菌菌株的抗生素耐药情况。
采用琼脂平板稀释法测定了1987 - 1992年期间从全国不同地区六个城市提交的淋病奈瑟菌菌株对青霉素、壮观霉素和头孢菌素的最低抑菌浓度（MIC），并采用快速碘量法检测产青霉素酶淋病奈瑟菌菌株的流行情况。
对青霉素耐药的菌株（MIC≥1.0微克/毫升）占所有分离株的57.5%。对壮观霉素耐药的菌株（MIC≥128微克/毫升）占1.3%，MIC接近耐药的菌株（MIC = 64微克/毫升）占4%。在来自南京和南宁市的419株分离株中有18株PPNG菌株（4.3%）。对头孢曲松和头孢噻肟耐药的菌株分别占2.6%和4.2%。
国内淋病奈瑟菌对青霉素的耐药情况较为严重，在治疗药物选择、患者随访及淋病监测方面应采取相应措施。
