Le Gal La Salle G, Feldblum S
Eur J Pharmacol. 1982 Dec 17;86(1):91-3. doi: 10.1016/0014-2999(82)90402-2.
The benzodiazepine antagonist RO 15-1788 was tested in an animal model of experimental epilepsy, the kindling effect. In animals fully kindled from repeated electrical amygdaloid stimulation, RO 15-1788 reversed the anticonvulsant effects of diazepam (2 mg/kg) from doses of 0.4-0.5 mg/kg. Doses up to 20 mg/kg also antagonized the preventive action of diazepam. RO 15-1788 alone had neither proconvulsant effects on the amygdaloid afterdischarges nor benzodiazepine-like activity on the kindled seizures.
