非甲非乙型肝炎：当代评估

Haematologia (Budap). 1982;15(2):153-73.

The current status of non-A, non-B (NANB) hepatitis is reviewed with respect to: (i) epidemiology and incidence of posttransfusion and sporadic NANB hepatitis; (ii) experimental transmission of NANB hepatitis; (iii) serologic tests and the evidence for virus-like NANB agents; (iv) clinical features of NANB hepatitis as compared to hepatitis B; (v) indication and impact of therapeutic and preventive measures against NANB hepatitis. Without specific markers for NANB infection, non-A, non-B hepatitis continues to be a diagnosis by exclusion of infection with hepatitis A, hepatitis B or other viruses. Recent observations suggest that NANB hepatitis may in fact be caused by a group of viruses immunologically different from but genetically similar to the hepatitis B virus.

本文就非甲非乙型（NANB）肝炎的现状进行了综述，内容涉及：（i）输血后和散发性NANB肝炎的流行病学及发病率；（ii）NANB肝炎的实验性传播；（iii）血清学检测及类病毒NANB病原体的证据；（iv）与乙型肝炎相比，NANB肝炎的临床特征；（v）针对NANB肝炎的治疗和预防措施的适应证及影响。由于缺乏NANB感染的特异性标志物，非甲非乙型肝炎仍然是通过排除甲型肝炎、乙型肝炎或其他病毒感染来做出的诊断。最近的观察结果表明，NANB肝炎实际上可能由一组在免疫学上与乙型肝炎病毒不同但在基因上相似的病毒引起。