丙型肝炎病毒与瘟病毒、黄病毒以及两个植物病毒超群的成员存在氨基酸序列相似性。
Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.
作者信息
Miller R H, Purcell R H
机构信息
Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
出版信息
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2057-61. doi: 10.1073/pnas.87.6.2057.
Abstract
Hepatitis C virus (HCV) is an important human pathogen that is associated with transfusion-related non-A, non-B hepatitis. Recently, HCV cDNA was cloned and the nucleotide sequence of approximately three-quarters of the virus genome was determined. A region of the predicted polyprotein sequence was found to share similarity with a nonstructural protein encoded by dengue virus, a member of the flavivirus family. We report here that HCV shares an even greater degree of protein sequence similarity with members of the pestivirus group (i.e., bovine viral diarrhea virus and hog cholera virus), which are thought to be distantly related to the flaviviruses. In addition, we find that HCV shares significant protein sequence similarity with the polyproteins encoded by members of the picornavirus-like and alphavirus-like plant virus supergroups. These data suggest that HCV may be evolutionarily related to both plant and animal viruses.
摘要
丙型肝炎病毒（HCV）是一种重要的人类病原体，与输血相关的非甲非乙型肝炎有关。最近，HCV cDNA被克隆出来，并且确定了大约四分之三病毒基因组的核苷酸序列。在预测的多蛋白序列区域中发现与黄病毒科成员登革病毒编码的一种非结构蛋白具有相似性。我们在此报告，HCV与瘟病毒属（即牛病毒性腹泻病毒和猪霍乱病毒）成员的蛋白质序列相似程度更高，而瘟病毒属被认为与黄病毒关系较远。此外，我们发现HCV与类微小核糖核酸病毒和类甲病毒植物病毒超群成员编码的多蛋白具有显著的蛋白质序列相似性。这些数据表明，HCV在进化上可能与植物病毒和动物病毒都有关系。
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