Jean-Faucher C, Berger M, de Turckheim M, Veyssiere G, Jean C
Int J Androl. 1982 Dec;5(6):627-35. doi: 10.1111/j.1365-2605.1982.tb00297.x.
Testicular development was evaluated in male mice subjected to undernutrition from birth to weaning (20 days) by separating pups from their mothers. Underfed and normally fed animals were sacrificed every 10 days from 20 to 60 days. From 20 to 60 days, body and testes weights were significantly lower in underfed males. In undernourished males, the establishment of spermatogenesis and the appearance of mature Leydig cells were delayed. The maximal production of testosterone by the testis of underfed males occurred later and was 50% lower than that of controls. The data shows that despite the hypoandrogenic state induced by undernutrition, puberty occurred and spermatogenesis was preserved.
通过将幼崽与母亲分开，对从出生到断奶（20天）期间遭受营养不足的雄性小鼠的睾丸发育进行了评估。从20天到60天，每隔10天处死一组营养不足和正常喂养的动物。在20至60天期间，营养不足的雄性小鼠的体重和睾丸重量明显较低。在营养不良的雄性小鼠中，精子发生的建立和成熟莱迪希细胞的出现有所延迟。营养不足的雄性小鼠睾丸产生睾酮的峰值出现较晚，且比对照组低50%。数据表明，尽管营养不足会导致雄激素缺乏状态，但青春期仍会出现且精子发生得以保留。
