Reimer G, Link I, Hauck H
Hautarzt. 1982 Dec;33(12):645-8.
A 25-year-old woman who had suffered from pemphigus for 2 years developed widespread, scalded skin-like lesions after stopping an immunosuppressive treatment. Histological and immunofluorescence studies confirmed the diagnosis of pemphigus erythematosus. Apart from IgG pemphigus antibodies, granular deposits for IgM at the dermoepidermal junction and circulating antinuclear IgM-antibodies could be detected. Despite of restarting an immunosuppressive regime, the patient developed severe hemophilia due to the occurrence of a factor VIII antiglobulin. Its possible immunopathologic basis is discussed.
一名患天疱疮2年的25岁女性在停用免疫抑制治疗后出现广泛的烫伤样皮损。组织学和免疫荧光研究证实为红斑型天疱疮。除了IgG天疱疮抗体外，还可检测到真皮表皮交界处的IgM颗粒沉积以及循环抗核IgM抗体。尽管重新开始免疫抑制治疗，但患者因出现因子VIII抗球蛋白而发生严重血友病。讨论了其可能的免疫病理基础。
