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用一种新的粘度测定方法检测经3'-甲基-4-二甲基氨基偶氮苯处理的大鼠肝脏DNA的粘度降低情况。

Decreased viscosity of rat-liver DNA treated by 3'-methyl-4-dimethylaminoazobenzene, detected with a new viscometric approach.

作者信息

Parodi S, Balbi C, Taningher M, Pala M, Russo P, Abelmoschi M L, Santi L

出版信息

Mutat Res. 1982 Nov;106(1):91-9. doi: 10.1016/0027-5107(82)90193-2.

DOI:10.1016/0027-5107(82)90193-2
PMID:6819481
Abstract

DNA damage induced in vivo by 3'-methyl-4-dimethylaminoazobenzene (3'CH3DAB) was investigated with 2 differently sensitive techniques: the alkaline elution assay and the viscometric measurement of DNA damage. 3'CH3DAB appeared to be falsely negative with the alkaline elution assay, whereas with the viscometric approach, which is about 30-50 times more sensitive, it appeared positive, and the DNA damage was dose-dependent.

摘要

利用两种不同灵敏度的技术研究了3'-甲基-4-二甲基氨基偶氮苯（3'CH3DAB）在体内诱导的DNA损伤：碱性洗脱分析和DNA损伤的粘度测定。碱性洗脱分析显示3'CH3DAB呈假阴性，而粘度测定法的灵敏度高出约30至50倍，显示其呈阳性，且DNA损伤具有剂量依赖性。

相似文献

1
Decreased viscosity of rat-liver DNA treated by 3'-methyl-4-dimethylaminoazobenzene, detected with a new viscometric approach.用一种新的粘度测定方法检测经3'-甲基-4-二甲基氨基偶氮苯处理的大鼠肝脏DNA的粘度降低情况。
Mutat Res. 1982 Nov;106(1):91-9. doi: 10.1016/0027-5107(82)90193-2.
2
Inhibition of mitochondrial electron transport and energy transduction by 2-methyl-4-dimethylaminoazobenzene in vitro.2-甲基-4-二甲基氨基偶氮苯对线粒体电子传递和能量转导的体外抑制作用。
Indian J Biochem Biophys. 1984 Oct;21(5):309-13.
3
[Induction of phenotypic changes and effect of AFP gene expression in newborn rat liver cells with N-methyl-N-nitro-N-nitrosoguanidine and 3'-methyl-4-dimethylaminoazobenzene in vitro].[用N-甲基-N-硝基-N-亚硝基胍和3'-甲基-4-二甲基氨基偶氮苯体外诱导新生大鼠肝细胞表型变化及甲胎蛋白基因表达的影响]
Shi Yan Sheng Wu Xue Bao. 1986 Jun;19(2):193-201.
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Effect of 3'-methyl-4-dimethylaminoazobenzene on arginine metabolism in rat liver.3'-甲基-4-二甲基氨基偶氮苯对大鼠肝脏精氨酸代谢的影响。
Indian J Biochem Biophys. 1982 Dec;19(6):411-4.
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The effect of 3'-methyl-4-demethyl-aminoazobenzene of foetal rat hepatocytes in culture.3'-甲基-4-脱甲基氨基偶氮苯对培养的胎鼠肝细胞的影响。
Eur J Cancer Clin Oncol. 1981 Jul;17(7):743-52. doi: 10.1016/0014-2964(81)90229-2.
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Elevation of serum albumin concentration in analbuminemic rats by administration of 3'-methyl-4-dimethylaminoazobenzene.通过给予3'-甲基-4-二甲基氨基偶氮苯提高无白蛋白血症大鼠的血清白蛋白浓度。
Biochem Biophys Res Commun. 1982 Jun 15;106(3):863-70. doi: 10.1016/0006-291x(82)91790-9.
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Effects of 3'-methyl-4-dimethylaminoazobenzene on RNA processing in rat liver nuclei.3'-甲基-4-二甲基氨基偶氮苯对大鼠肝细胞核中RNA加工的影响。
Carcinogenesis. 1987 Aug;8(8):1039-42. doi: 10.1093/carcin/8.8.1039.
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Effect of phenobarbital and 3-methylcholanthrene on decrease in pH in liver induced by 3'-methyl-4-dimethylaminoazobenzene, of partial hepatectomy and hepatotoxic agents.苯巴比妥和3-甲基胆蒽对3'-甲基-4-二甲基氨基偶氮苯、部分肝切除术及肝毒性药物所致肝脏pH值降低的影响。
Chem Pharm Bull (Tokyo). 1979 Mar;27(3):586-91. doi: 10.1248/cpb.27.586.
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Effect of phenobarbital on adult rat liver cells treated with 3'-methyl-4-dimethylaminoazobenzene in primary culture.苯巴比妥对原代培养中经3'-甲基-4-二甲基氨基偶氮苯处理的成年大鼠肝细胞的影响。
J Cancer Res Clin Oncol. 1985;110(3):191-5. doi: 10.1007/BF00399272.
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Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene.2-甲基-4-二甲基氨基偶氮苯对线粒体氧化磷酸化的抑制作用。
Biochim Biophys Acta. 1984 Jul 27;766(1):263-6. doi: 10.1016/0005-2728(84)90240-8.

引用本文的文献

1
Studies on DNA damage: discordant responses of rate of DNA disentanglement (viscosimetrically evaluated) and alkaline elution rate, obtained for several compounds. Possible explanations of the discrepancies.
Cell Biophys. 1983 Dec;5(4):285-300. doi: 10.1007/BF02788627.