Knop J, Stritzke P, Heller M, Redeker S, Crone-Münzebrock W
Z Rheumatol. 1982 Nov-Dec;41(6):272-5.
After an average of 5 years following therapy with Ra224, the concentration of Tc99m methyl diphosphonate (MDP) in the region of the sacroiliac joints and lumbar spine was measured in 15 patients with ankylosing spondylitis. The findings were supplemented by those of clinical, pathological, and roentgenological examinations. The concentration of MDP was normal in the sacroiliac joints in almost all the patients, but was raised in the lumbar spine in two-thirds. This is to be interpreted as indicating enhanced bone turnover, the difference from that in healthy subjects being highly significant (p less than 1). Increased ossification of the lumbar spine could be demonstrated roentgenologically in two-thirds of the patients. Differential blood count, blood sedimentation rate, and electrophoresis remained unchanged after therapy. However, in 60% of patients the mobility of the spine was the same or even improved; 46% felt better after Ra224 treatment than before it.
在用镭224治疗平均5年后，对15例强直性脊柱炎患者测量了骶髂关节和腰椎区域锝99m亚甲基二膦酸盐（MDP）的浓度。临床、病理和放射学检查结果对这些发现起到了补充作用。几乎所有患者的骶髂关节中MDP浓度正常，但三分之二患者的腰椎中MDP浓度升高。这被解释为表明骨转换增强，与健康受试者相比差异非常显著（p小于1）。三分之二的患者经放射学检查可显示腰椎骨化增加。治疗后白细胞分类计数、血沉和电泳均未改变。然而，60%的患者脊柱活动度相同甚至有所改善；46%的患者在接受镭224治疗后感觉比治疗前更好。
