Daniel R M, Cowan D A, Morgan H W, Curran M P
Biochem J. 1982 Dec 1;207(3):641-4. doi: 10.1042/bj2070641.
The loss of activity due to proteolysis of purified L-asparaginase and beta-galactosidase from different sources correlates with the thermal instability of the enzymes. A similar correlation is found when populations of soluble proteins from micro-organisms grown at different temperatures are compared for proteolytic susceptibility and thermal stability. It is proposed that there is a general correlation between the thermostability of proteins and their resistance to proteolysis.
不同来源的纯化L-天冬酰胺酶和β-半乳糖苷酶因蛋白水解导致的活性丧失与酶的热不稳定性相关。当比较在不同温度下生长的微生物的可溶性蛋白质群体的蛋白水解敏感性和热稳定性时,也发现了类似的相关性。有人提出,蛋白质的热稳定性与其抗蛋白水解能力之间存在普遍的相关性。