Morley T R, Short M D, Dowsett D J
J Nucl Med. 1978 Aug;19(8):884-90.
A method for quantifying the uptake of Tc-99m-labeled phosphate complexes in the femoral head has been clinically evaluated, being used specifically for studying the uptake of these bone-seeking agents in Perthes' disease. The analysis depends on the selection, by computer program, of a reliable reference area in the femoral shaft, which is then compared with the mean uptake from each femoral head. The femoral-head activity is then represented as an uptake ratio. These ratios, together with a fixed contour representing the uptake in the femoral-head regions, provide more clinical information than the radiograph or scintiphoto, particularly in the early stages of unilateral or bilateral femoral-head disease and during followup. No correlation has been found between these ratios and qualitative techniques for assessing Perthes' disease by radiograph. From the quantitative data so far obtained it is clear that osteotomy reduces the vascularity of the femoral head, and in certain cases this reduction persists for some years. Tc-99m-labeled diphosphonate compounds were used in more recent studies, and a significant increase in sensitivity was obtained, compared with earlier polyphosphate data.
一种定量测定股骨头中锝-99m标记的磷酸盐复合物摄取情况的方法已得到临床评估，该方法专门用于研究佩特兹病中这些亲骨性药物的摄取情况。分析依赖于通过计算机程序在股骨干中选择一个可靠的参考区域，然后将其与每个股骨头的平均摄取量进行比较。然后将股骨头的活性表示为摄取率。这些比率，连同代表股骨头区域摄取情况的固定轮廓，比X线片或闪烁照片提供了更多的临床信息，特别是在单侧或双侧股骨头疾病的早期阶段以及随访期间。尚未发现这些比率与通过X线片评估佩特兹病的定性技术之间存在相关性。从目前获得的定量数据来看，很明显截骨术会降低股骨头的血管供应，并且在某些情况下这种降低会持续数年。在最近的研究中使用了锝-99m标记的二膦酸盐化合物，与早期的多磷酸盐数据相比，敏感性有了显著提高。
