Ohno S
Trans Ophthalmol Soc U K (1962). 1981 Sep;101 (Pt 3)(3):335-41.
Immunogenetic studies showed that Behçet's disease has a primary association with HLA-B antigen (HLA-BW51) and the same association throughout the world, whereas, Vogt-Koyanagi-Harada's disease (VKH) is primarily associated with supertypic HLA-DR antigen (MT3), an HLA-D-linked B cell alloantigen in Japanese. Immunological investigation showed that the serum levels of gamma-interferon (IFN-gamma) were significantly increased in both Behçet's disease and VKH, IFN-gamma showed a significant decrease in the ocular exacerbation stage in Behçet's disease. The highest IFN titre was observed 1 to 2 months after the onset of the disease in VKH.
免疫遗传学研究表明，白塞病与HLA - B抗原（HLA - BW51）存在主要关联，且在全球范围内情况相同；而小柳原田病（VKH）主要与超型HLA - DR抗原（MT3）相关，MT3是日本人中一种与HLA - D连锁的B细胞同种异体抗原。免疫学调查显示，白塞病和VKH患者血清中的γ-干扰素（IFN - γ）水平均显著升高，在白塞病的眼部加重期IFN - γ显著降低。VKH患者在发病后1至2个月观察到最高的IFN滴度。
