Job J C, Chaussain J L, Toublanc J E
Ann Endocrinol (Paris). 1982 Dec;43(6):435-51.
Delayed puberty is defined as the total or almost total absence of development of sex characteristics at an age exceeding the mean by two standard deviations: approximately 15 years in boys and 13 years in girls. A double sense has been given to this term, which is usually applied to permanent hypogonadism as well as to normal but delayed maturation. In practice, certain signs can assist formulation of a prognosis, and if necessary the type of therapy required. Data on which can be based the diagnosis, surveillance, and medical conduct in sexually immature adolescents are discussed. Their interpretation is simple when elevated gonadotrophins levels indicate a primary gonadal lesion, or when the delayed puberty results from a general disease disturbing body maturation. In other cases, interpretation of data is often very difficult and is sometimes a very slow process. Because of these difficulties, the diagnosis between simple delay and gonadotrophic insufficiency is discussed in this report on the basis of a retrospective study conducted for a long enough period to have arrived at a definite conclusion.
青春期延迟的定义是，在超过平均年龄两个标准差的年龄时，性征完全或几乎完全未发育：男孩约为15岁，女孩约为13岁。这个术语有双重含义，通常适用于永久性性腺功能减退以及正常但延迟的成熟情况。在实践中，某些体征有助于判断预后，以及在必要时确定所需的治疗类型。本文讨论了性发育不成熟青少年的诊断、监测和医疗行为所依据的数据。当促性腺激素水平升高表明原发性性腺病变，或者青春期延迟是由干扰身体成熟的全身性疾病引起时，对这些数据的解读很简单。在其他情况下，数据解读往往非常困难，有时是一个非常缓慢的过程。由于这些困难，本报告基于一项进行了足够长时间以得出明确结论的回顾性研究，讨论了单纯延迟与促性腺激素功能不全之间的诊断。
