Tomioka M, Usami M, Sakamoto A
Gan To Kagaku Ryoho. 1982 Aug;9(8):1374-9.
Futraful suppository 1.5 g per day was administered to 33 patients with head and neck malignancies. Among 33 cases which entered into the study, 16 cases were evaluated. Out of 16 evaluable cases, complete responses (CRs) were obtained in 4 cases and partial responses (PRs) in 7 cases, an overall response rate including 4 CRs and 7 PRs was 68.8%. Side effects due to FT-207 suppository were developed in 14 cases out of 33 patients (42.4%). Side effects such as anal pain, anorexia, diarrhea, pigmentation, exanthema and nail change were observed. No severe side effect was encountered.
每天给33例头颈部恶性肿瘤患者使用1.5克氟尿嘧啶栓。在进入该研究的33例患者中，有16例接受了评估。在16例可评估的病例中，4例获得完全缓解（CR），7例获得部分缓解（PR），包括4例CR和7例PR的总缓解率为68.8%。33例患者中有14例（42.4%）出现了氟尿嘧啶栓引起的副作用。观察到肛门疼痛、厌食、腹泻、色素沉着、皮疹和指甲改变等副作用。未遇到严重副作用。
