Akimoto M, Abe R, Kasai M
Gan To Kagaku Ryoho. 1982 Aug;9(8):1387-93.
Immuno-chemotherapeutic effect on growth of 81B mammary tumor was studied in syngeneic C3H/He mice fed diet with low (D) or normal (N) protein content. 1. 5-FU 20 mg/kg. was given intra-peritoneal daily for 3 weeks. The tumor volume ratio (T/C) was significantly reduced on day 14 in both N and D-group mice. However, all mice were dead 2 weeks after administration of 5-FU in D-group mice. 2. Immuno-potentiator OK-432 (50 KE/kg,) or Lentinan (5 mg/kg,) was given i.p. daily for 3 weeks. The 81B tumor growth was inhibited on day 14 in N-group mice. However, the tumor growth was paradoxically accelerated after administration of these agents in D-group mice. Augmentation of the natural killer cell activity was recognized in N-group mice treated with OK-432 or Lentinan, but no change was seen in D-group mice. 3. After administration of 5-FU, intra-tumoral concentration of 5-FU was higher in N-group mice than that of in D-group mice.
在喂食低蛋白（D）或正常蛋白（N）含量饮食的同基因C3H/He小鼠中，研究了免疫化疗对81B乳腺肿瘤生长的影响。1. 每天腹腔注射5-氟尿嘧啶（5-FU）20毫克/千克，持续3周。在第14天，N组和D组小鼠的肿瘤体积比（T/C）均显著降低。然而，D组小鼠在给予5-FU后2周全部死亡。2. 每天腹腔注射免疫增强剂OK-432（50KE/千克）或香菇多糖（5毫克/千克），持续3周。在第14天，N组小鼠的81B肿瘤生长受到抑制。然而，在D组小鼠中给予这些药物后，肿瘤生长却反常地加速。在用OK-432或香菇多糖治疗的N组小鼠中，自然杀伤细胞活性增强，但D组小鼠未见变化。3. 给予5-FU后，N组小鼠肿瘤内5-FU浓度高于D组小鼠。
