吸入暴露后F-344大鼠中正己烷的剂量依赖性处置。

Dose-dependent disposition of n-hexane in F-344 rats after inhalation exposure.

作者信息

Bus J S, Deyo D, Cox M

出版信息

Fundam Appl Toxicol. 1982 Sep-Oct;2(5):226-9. doi: 10.1016/s0272-0590(82)80031-6.

Abstract

The purpose of this study was to assess the disposition of radioactivity in rats after single inhalation exposures to varying concentrations of [1,2-14C]-n-hexane. Male Fischer 344 rats were exposed to 500, 1000, 3000 or 10,000 ppm 14C-n-hexane for 6 hr and the elimination of radioactivity followed for 72 hr after exposure. The disposition of radioactivity was dose-dependent, with 12, 24, 38 and 62% of the acquired body burden excreted as n-hexane by the lung with increasing exposure concentration. In contrast, 38, 31, 27 and 18% of the body burden of radioactivity was recovered as expired 14CO2 and 35, 40, 31 and 18% was recovered in the urine with increasing n-hexane concentration. Radioactivity remaining in the tissues and carcass 72 hr after exposure represented 6.1, 8.8, 7.4 and 5.4% of the body burden for the respective exposures. The dose-dependent elimination of radioactivity was apparently due in part to an inhibition of n-hexane metabolism, reflected by a decrease in total 14CO2 and urinary 14C excretion after 10,000 ppm exposure compared to the 3000 ppm exposure.

摘要

本研究的目的是评估大鼠单次吸入不同浓度的[1,2-¹⁴C]-正己烷后放射性的分布情况。雄性Fischer 344大鼠暴露于500、1000、3000或10,000 ppm的¹⁴C-正己烷中6小时，并在暴露后追踪72小时放射性的消除情况。放射性的分布呈剂量依赖性，随着暴露浓度的增加，肺部以正己烷形式排出的获得性体内负荷分别为12%、24%、38%和62%。相比之下，随着正己烷浓度的增加，呼出的¹⁴CO₂中回收的放射性体内负荷分别为38%、31%、27%和18%，尿液中回收的分别为35%、40%、31%和18%。暴露72小时后，组织和 carcass 中残留的放射性分别占各自暴露时体内负荷的6.1%、8.8%、7.4%和5.4%。放射性的剂量依赖性消除显然部分归因于正己烷代谢的抑制，这表现为与3000 ppm暴露相比，10,000 ppm暴露后总¹⁴CO₂和尿¹⁴C排泄量减少。