Lajos J
Haematologia (Budap). 1982;15(3):315-21.
Seventeen Rh negative pregnant women who had Rhesus alloantibodies were investigated serologically. The antibody-mediated cellular cytotoxicity (ADCC) against target Rhesus positive human erythrocytes was determined. The investigation was repeated in the first, second and third trimester of pregnancy and after delivery. There was no correlation between ADCC and antibody titre. The antibody titre and the cytotoxic index increased during pregnancy, but the cytotoxic index decreased after delivery. The cytotoxic index showed individual characteristics and was quite independent of the titre of anti-D. There was no correlation between the heavy chain type of anti-D and the cytotoxic index. Our data suggest that the individual variations during pregnancy of the supposed cytotoxic antibody acting together with anti-D play an important role in pregnancy and delivery.
对17名怀有恒河猴同种抗体的Rh阴性孕妇进行了血清学调查。测定了针对恒河猴阳性人红细胞的抗体介导细胞毒性（ADCC）。在妊娠的第一、第二和第三个月以及分娩后重复进行该调查。ADCC与抗体滴度之间没有相关性。抗体滴度和细胞毒性指数在妊娠期间升高，但在分娩后细胞毒性指数下降。细胞毒性指数显示出个体特征，并且与抗-D滴度相当独立。抗-D的重链类型与细胞毒性指数之间没有相关性。我们的数据表明，假定的细胞毒性抗体在妊娠期间的个体差异与抗-D共同作用在妊娠和分娩中起重要作用。
