Szadowska A, Szmigielska H, Szmigielski A
Acta Physiol Pol. 1982 Sep-Dec;33(5-6):447-53.
In the first part of the study penetration of blood-brain barrier by lysine vasopressin (LVP) was studied. After i.p. injection 125J-LVP or its large fragments appeared in the hypothalamus, hippocampus, tuberculum olfactorium and brain stem. In these structures the effect of i.p. injected LVP on noradrenaline level and turnover rate was studied. LVP produced an increase of noradrenaline level in the hypothalamus, hippocampus and tuberculum olfactorium. In the brain stem no marked changes in noradrenaline content were found. In all the examined brain structures LVP slowed down turnover rate of noradrenaline.
在该研究的第一部分，对赖氨酸加压素（LVP）通过血脑屏障的渗透情况进行了研究。腹腔注射125I-LVP或其大片段后，在下丘脑、海马体、嗅结节和脑干中出现了放射性。在这些结构中，研究了腹腔注射LVP对去甲肾上腺素水平和周转率的影响。LVP使下丘脑、海马体和嗅结节中的去甲肾上腺素水平升高。在脑干中，未发现去甲肾上腺素含量有明显变化。在所有检测的脑结构中，LVP均减缓了去甲肾上腺素的周转率。
