Szadowska A, Szmigielska H, Szmigielski A
Acta Physiol Pol. 1976 May-Jun;27(3):265-8.
Turnover of noradrenaline (NA) and dopamine (DA) in some regions of the rat brain was determined after 1 and 3 weeks of daily injections of lysine vasopressin (LVP) and 2 weeks after the termination of 28-day LVP injections. Disappearance of 3H-DA was estimated in the hemispheres, brain stem and striatum and of 3H-NA in the hemispheres and brain stem after intraventricular injection of 3H-tyrosine. A significant acceleration of 3H-NA disappearance from the hemispheres was found in all the experimental animals and from the brain stem 3 weeks after LVP adminstration and 2 weeks after its withdrawal. No marked changes in dopamine turnover in the examined regions of the rat brain were found. Since prolonged vasopressin administration produces hypertension in the rat it seems likely that central NA, but not DA, plays a role in the vasopressin-induced hypertension.
在大鼠每日注射赖氨酸加压素（LVP）1周和3周后，以及在28天LVP注射终止2周后，测定了大鼠脑某些区域去甲肾上腺素（NA）和多巴胺（DA）的周转率。在脑室内注射3H-酪氨酸后，估计半球、脑干和纹状体中3H-DA的消失情况，以及半球和脑干中3H-NA的消失情况。在所有实验动物中，发现LVP给药3周后及停药2周后，半球中3H-NA的消失显著加速，脑干中也是如此。在大鼠脑的检测区域中，未发现多巴胺周转率有明显变化。由于长期给予加压素会使大鼠产生高血压，因此中枢NA而非DA似乎在加压素诱导的高血压中起作用。
